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1

Pharmacological Treatments for Autism Spectrum Disorder: Will Emerging Approaches Yield New Treatments?

Gogliotti, Rocco G, Conn, P Jeffrey

Journal:

Neuropsychopharmacology

Year:

2016

Language:

english

File:

PDF, 123 KB

english, 2016

2

Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor

Bruce J. Melancon, Rocco D. Gogliotti, James C. Tarr, Sam A. Saleh, Brian A. Chauder, Evan P. Lebois, Hyekyung P. Cho, Thomas J. Utley, Douglas J. Sheffler, Thomas M. Bridges, Ryan D. Morrison, J. Sco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.81 MB

english, 2012

3

The Metabotropic Glutamate Receptor 4 Positive Allosteric Modulator ADX88178 Inhibits Inflammatory Responses in Primary Microglia

Ponnazhagan, Ranjani, Harms, Ashley S., Thome, Aaron D., Jurkuvenaite, Asta, Gogliotti, Rocco, Niswender, Colleen M., Conn, P. Jeffrey, Standaert, David G.

Journal:

Journal of Neuroimmune Pharmacology

Year:

2016

Language:

english

File:

PDF, 714 KB

english, 2016

4

Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines

Abe, Masahito, Seto, Mabel, Gogliotti, Rocco G, Loch, Matthew T., Bollinger, Katrina A, Chang, Sichen, Engelberg, Eileen M, Luscombe, Vincent B, Harp, Joel, Bubser, Michael, Engers, Darren W., Jones,

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

5

A new class of anti-HIV-1 agents targeted toward the nucleocapsid protein NCp7: The 2,2′-dithiobisbenzamides

John M. Domagala, John P. Bader, Rocco D. Gogliotti, Joseph P. Sanchez, Michael A. Stier, Yuntao Song, J.V.N. Vara Prasad, Peter J. Tummino, Jeffrey Scholten, Patricia Harvey, Tod Holler, Steve Grache

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 955 KB

english, 1997

6

2,2′-dithiobisbenzamides derived from α-, β- and γ-amino acids possessing anti-HIV activities: synthesis and structure–activity relationship

J.V.N Vara Prasad, Joseph A Loo, Frederick E Boyer, Michael A Stier, Rocco D Gogliotti, William J Turner, Patricia J Harvey, Melissa R Kramer, David P Mack, Jefferey D Scholten, Stephen J Gracheck, Jo

Journal:

Bioorganic & Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 367 KB

english, 1998

7

The synthesis of a series of 7-amino-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids as potential antibacterial agents

Joseph P. Sanchez, Rocco D. Gogliotti

Journal:

Journal of Heterocyclic Chemistry

Year:

1993

File:

PDF, 387 KB

1993

8

Inhibition of the early phase of HIV replication by an isothiazolone, PD 161374

Lamia Sharmeen, Thomas McQuade, Andrea Heldsinger, Rocco Gogliotti, John Domagala, Stephen Gracheck

Journal:

Antiviral Research

Year:

2001

Language:

english

File:

PDF, 275 KB

english, 2001

9

The Synthesis, Structure-Activity, and Structure-Side Effect Relationships of a Series of 8-Alkoxy- and 5-Amino-8-alkoxyquinolone Antibacterial Agents

Sanchez, Joseph P., Gogliotti, Rocco D., Domagala, John M., Gracheck, Stephen J., Huband, Michael D., Sesnie, Josephine A., Cohen, Michael A., Shapiro, Martin A.

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

10

Biophysical Characterization of Zinc Ejection from HIV Nucleocapsid Protein by Anti-HIV 2,2‘-Dithiobis[benzamides] and Benzisothiazolones

Loo, Joseph A., Holler, Tod P., Sanchez, Joseph, Gogliotti, Rocco, Maloney, Lisa, Reily, Michael D.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 271 KB

english, 1996

11

Discovery, Synthesis, and Structure–Activity Relationship Development of a Series of N -4-(2,5-Dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): Characterization of a Novel Positive Allosteric Modulator of the Metabotropic Glutamate Receptor 4 (mGlu 4 ) with Oral Efficacy in an Antiparkinsonian Animal Model

Jones, Carrie K., Engers, Darren W., Thompson, Analisa D., Field, Julie R., Blobaum, Anna L., Lindsley, Stacey R., Zhou, Ya, Gogliotti, Rocco D., Jadhav, Satyawan, Zamorano, Rocio, Bogenpohl, Jim, Smi

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 515 KB

english, 2011

12

Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in In Vivo Activity

Rook, Jerri M., Noetzel, Meredith J., Pouliot, Wendy A., Bridges, Thomas M., Vinson, Paige N., Cho, Hyekyung P., Zhou, Ya, Gogliotti, Rocco D., Manka, Jason T., Gregory, Karen J., Stauffer, Shaun R.,

Journal:

Biological Psychiatry

Year:

2013

Language:

english

File:

PDF, 1.22 MB

english, 2013

13

The in vitro Ejection of Zinc from Human Immunodeficiency Virus (HIV) Type 1 Nucleocapsid Protein by Disulfide Benzamides with Cellular Anti-HIV Activity

Peter J. Tummino, Jeffrey D. Scholten, Patricia J. Harvey, Tod P. Holler, Lisa Maloney, Rocco Gogliotti, John Domagala and Donald Hupe

Journal:

Proceedings of the National Academy of Sciences

Year:

1996

Language:

english

File:

PDF, 955 KB

english, 1996

14

Role of Inhibitor Aliphatic Chain in the Thermodynamics of Inhibitor Binding to Escherichia coli Enoyl-ACP Reductase and the Phe203Leu Mutant: A Proposed Mechanism for Drug Resistance †

Protasevich, Irina I., Brouillette, Christie G., Snow, Mark E., Dunham, Steve, Rubin, J. Ronald, Gogliotti, Rocco, Siegel, Karen

Journal:

Year:

2004

Language:

english

File:

PDF, 205 KB

english, 2004

15

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

He, Shihan, Senter, Timothy J., Pollock, Jonathan, Han, Changho, Upadhyay, Sunil Kumar, Purohit, Trupta, Gogliotti, Rocco D., Lindsley, Craig W., Cierpicki, Tomasz, Stauffer, Shaun R., Grembecka, Jola

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 5.59 MB

english, 2014

16

Exploration of Allosteric Agonism Structure–Activity Relationships within an Acetylene Series of Metabotropic Glutamate Receptor 5 (mGlu 5 ) Positive Allosteric Modulators (PAMs): Discovery of 5-((3-Fluorophenyl)ethynyl)- N -(3-methyloxetan-3-yl)picolinamide (ML254)

Turlington, Mark, Noetzel, Meredith J., Chun, Aspen, Zhou, Ya, Gogliotti, Rocco D., Nguyen, Elizabeth D., Gregory, Karen J., Vinson, Paige N., Rook, Jerri M., Gogi, Kiran K., Xiang, Zixiu, Bridges, Th

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 3.74 MB

english, 2013

17

Quinolone antibacterials: preparation and activity of bridged bicyclic analogues of the C7-piperazine

Kiely, John S., Hutt, Marland P., Culbertson, Townley P., Bucsh, Ruth A., Worth, Donald F., Lesheski, Lawrence E., Gogliotti, Rocco D., Sesnie, Josephine C., Solomon, Marjorie, Mich, Thomas F.

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 966 KB

english, 1991

18

Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility

Senter, Timothy, Gogliotti, Rocco D., Han, Changho, Locuson, Charles W., Morrison, Ryan, Daniels, J. Scott, Cierpicki, Tomasz, Grembecka, Jolanta, Lindsley, Craig W., Stauffer, Shaun R.

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.64 MB

english, 2015

19

mGlu 5 Positive Allosteric Modulation Normalizes Synaptic Plasticity Defects and Motor Phenotypes in a Mouse Model of Rett Syndrome

Gogliotti, Rocco G., Klar, Rebecca, Rook, Jerri M., Ghoshal, Ayan, Zamorano, Rocio, Malosh, Chyrsa, Stauffer, Shaun R., Bridges, Thomas M., Bartolome, Jose M., Daniels, J. Scott, Jones, Carrie, Lindsl

Journal:

Human Molecular Genetics

Year:

2016

Language:

english

File:

PDF, 1.66 MB

english, 2016

20

Discovery, Synthesis and Pre-Clinical Characterization of N-(3-chloro-4-fluorophenyl)-1H-pyrazolo[4,3-b]pyridin-3-amine (VU0418506), a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu4)

Engers, Darren W., Blobaum, Anna L., Gogliotti, Rocco D., Cheung, Yiu-Yin, Salovich, James M., Garcia-Barrantes, Pedro M., Daniels, J. Scott, Morrison, Ryan, Jones, Carrie K., Soars, Matthew G., Zhuo,

Journal:

ACS Chemical Neuroscience

Year:

2016

Language:

english

File:

PDF, 620 KB

english, 2016

21

Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy

Gogliotti, Rocco D., Engers, Darren W., Garcia-Barrantes, Pedro M., Panarese, Joseph D., Gentry, Patrick R., Blobaum, Anna L., Morrison, Ryan D., Daniels, J. Scott, Thompson, Analisa D., Jones, Carrie

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.21 MB

english, 2016

22

Discovery and characterization of a novel series of N-phenylsulfonyl-1H-pyrrole picolinamides as positive allosteric modulators of the metabotropic glutamate receptor 4 (mGlu4)

Gogliotti, Rocco D., Blobaum, Anna L., Morrison, Ryan M., Daniels, J. Scott, Salovich, James M., Cheung, Yiu-Yin, Rodriguez, Alice L., Loch, Matthew T., Conn, P. Jeffrey, Lindsley, Craig W., Niswender

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 2.85 MB

english, 2016

23

NIH Public Access

Blobaum, L, Lindsley, Stacey R, Zhou, Ya, Gogliotti, Rocco D

Year:

2012

Language:

english

File:

PDF, 845 KB

english, 2012

24

mGlu 7 potentiation rescues cognitive, social, and respiratory phenotypes in a mouse model of Rett syndrome

Gogliotti, Rocco G., Senter, Rebecca K., Fisher, Nicole M., Adams, Jeffrey, Zamorano, Rocio, Walker, Adam G., Blobaum, Anna L., Engers, Darren W., Hopkins, Corey R., Daniels, J. Scott, Jones, Carrie K

Journal:

Science Translational Medicine

Year:

2017

Language:

english

File:

PDF, 799 KB

english, 2017

25

Genetic Reduction or Negative Modulation of mGlu 7 Does Not Impact Anxiety and Fear Learning Phenotypes in a Mouse Model of MECP2 Duplication Syndrome

Fisher, Nicole M., Gogliotti, Rocco G., Vermudez, Sheryl Anne D., Stansley, Branden J., Conn, P. Jeffrey, Niswender, Colleen M.

Journal:

ACS Chemical Neuroscience

Year:

2017

Language:

english

File:

PDF, 1.95 MB

english, 2017

26

Contextual Fear Extinction Induces Hippocampal Metaplasticity Mediated by Metabotropic Glutamate Receptor 5

Stansley, Branden J, Fisher, Nicole M, Gogliotti, Rocco G, Lindsley, Craig W, Conn, P Jeffrey, Niswender, Colleen M

Journal:

Cerebral Cortex

Year:

2017

Language:

english

File:

PDF, 904 KB

english, 2017

27

Total RNA-sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target

Gogliotti, Rocco, Fisher, Nicole, Stansley, Branden, Jones, Carrie, Lindsley, Craig, Conn, Jeffrey, Niswender, Colleen

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2018

Language:

english

File:

PDF, 2.41 MB

english, 2018

28

Discovery of Potent 2-Aryl-6,7-Dihydro-5 H -Pyrrolo[1,2- a ]imidazoles as WDR5 WIN-site Inhibitors Using Fragment-Based Methods and Structure-Based Design

Wang, Feng, Jeon, Kyu Ok, Salovich, James M., Macdonald, Jonathan D, Alvarado, Joseph, Gogliotti, Rocco D., Phan, Jason, Olejniczak, Edward T, Sun, Qi, Wang, Shidong, Camper, DeMarco V., Yuh, Joannes

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 6.22 MB

english, 2018

29

Eliciting Renal Failure in Mosquitoes with a Small-Molecule Inhibitor of Inward-Rectifying Potassium Channels

Raphemot, Rene, Rouhier, Matthew F., Hopkins, Corey R., Gogliotti, Rocco D., Lovell, Kimberly M., Hine, Rebecca M., Ghosalkar, Dhairyasheel, Longo, Anthony, Beyenbach, Klaus W., Denton, Jerod S., Pier

Journal:

Year:

2013

Language:

english

File:

PDF, 620 KB

english, 2013

30

Discovery, Characterization, and Structure?Activity Relationships of an Inhibitor of Inward Rectifier Potassium (Kir) Channels with Preference for Kir2.3, Kir3.X, and Kir7.1

Raphemot, Rene, Lonergan, Daniel F., Nguyen, Thuy T., Utley, Thomas, Lewis, L. Michelle, Kadakia, Rishin, Weaver, C. David, Gogliotti, Rocco, Hopkins, Corey, Lindsley, Craig W., Denton, Jerod S.

Journal:

Frontiers in Pharmacology

Year:

2011

Language:

english

File:

PDF, 3.14 MB

english, 2011

31

Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress

Joffe, Max E., Santiago, Chiaki I., Stansley, Branden J., Maksymetz, James, Gogliotti, Rocco G., Engers, Julie L., Nicoletti, Ferdinando, Lindsley, Craig W., Conn, P. Jeffrey

Journal:

Neuropharmacology

Year:

2019

Language:

english

File:

PDF, 1.90 MB

english, 2019

32

Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity

Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvar

Journal:

Year:

2019

Language:

english

File:

PDF, 4.08 MB

english, 2019

33

mGlu 5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu 5 -Endocannabinoid Signaling

Xiang, Zixiu, Lv, Xiaohui, Maksymetz, James, Stansley, Branden J., Ghoshal, Ayan, Gogliotti, Rocco G., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey

Journal:

ACS Pharmacology & Translational Science

Year:

2019

Language:

english

File:

PDF, 4.28 MB

english, 2019

34

Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Tian, Jianhua, Teuscher, Kevin, Aho, Erin R., Alvarado, Joseph R., Mills, Jonathan J., Meyers, Kenneth M., Gogliotti, Rocco D., Han, Changho, Macdonald, Jonathan D, Sai, Jiqing, Shaw, J. Grace, Sensin

Journal:

Journal of Medicinal Chemistry

Year:

2019

Language:

english

File:

PDF, 6.77 MB

english, 2019

35

In Vitro to in Vivo Translation of Allosteric Modulator Concentration-Effect Relationships: Implications for Drug Discovery

Gregory, Karen J., Bridges, Thomas M., Gogliotti, Rocco G., Stauffer, Shaun R., Noetzel, Meredith J., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.

Journal:

ACS Pharmacology & Translational Science

Year:

2019

File:

PDF, 2.19 MB

2019

36

Discovery and Structure-Based Optimization of Potent and Selective WD repeat domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core

Tian, Jianhua, Teuscher, Kevin, Aho, Erin R., Alvarado, Joseph R., Mills, Jonathan J., Meyers, Kenneth M., Gogliotti, Rocco D., Han, Changho, Macdonald, Jonathan D, Sai, Jiqing, Shaw, J. Grace, Sensin

Journal:

Journal of Medicinal Chemistry

Year:

2019

File:

PDF, 6.77 MB

2019

37

Phenotypic profiling of mGlu 7 knockout mice reveals new implications for neurodevelopmental disorders

Fisher, Nicole M., Gould, Robert W., Gogliotti, Rocco G., McDonald, Annalise J., Badivuku, Hana, Chennareddy, Susmita, Buch, Aditi B., Moore, Annah M., Jenkins, Matthew T., Robb, W. Hudson, Lindsley,

Journal:

Genes, Brain and Behavior

Year:

2020

Language:

english

File:

PDF, 1.36 MB

english, 2020